Paradoxical increase in circulating Aspergillus antigen during treatment with caspofungin in a patient with pulmonary aspergillosis.

نویسندگان

  • Rocus R Klont
  • Monique A S H Mennink-Kersten
  • Dorien Ruegebrink
  • Antonius J M M Rijs
  • Nicole M A Blijlevens
  • J Peter Donnelly
  • Paul E Verweij
چکیده

A paradoxical increase in circulating Aspergillus antigen was observed during treatment with caspofungin in a patient with proven invasive aspergillosis. With the exception of treatment with the echinocandin, no other factors were found that might explain this clinical observation, which was supported by experiments done in vitro.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fatal invasive aspergillosis caused by Aspergillus niger after bilateral lung transplantation

Aspergillus niger is usually considered to be a low virulence fungus, not commonly reported to cause invasive infections. Invasive pulmonary aspergillosis due to Aspergillus niger was diagnosed in a 43-year-old woman following bilateral lung transplantation. Intravenous voriconazole failed to control progression of the disease. Despite salvage therapy with a combination of voriconazole and casp...

متن کامل

Tumor shape pulmonary mucormycosis associated with sinonasal aspergillosis in a diabetic patient

Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphoter...

متن کامل

In vitro susceptibility to amphotericin B, itraconazole, voriconazole, posaconazole and caspofungin of Aspergillus spp. isolated from patients with haematological malignancies in Tunisia

The resistance of Aspergillus species to antifungal is increasingly reported and the knowledge of the local epidemiology and antifungal susceptibility pattern is pivotal to define adequate treatment policies. Our study aimed to: 1) describe the in vitro antifungal susceptibility profile of the Aspergillus species isolated from patients with haematological malignancies in Tunisia; 2) compare the...

متن کامل

Changes of serum aspergillus galactomannan during hematopoietic stem cell transplantation in children with prior invasive aspergillosis

BACKGROUND Invasive aspergillosis (IA) has recently increased and has a high mortality rate in immunocompromised patients. IA before hematopoietic stem cell transplantation (HSCT) is not uncommon, but how to cope with it is very tough. The serum aspergillus galactomannan antigen (GM) is a helpful marker for diagnosis of IA, and a serial follow-up of GM levels is important to evaluate the respon...

متن کامل

Caspofungin: cross-reactivity in the Aspergillus antigen assay.

The Platelia Aspergillus antigen enzyme-linked immunosorbent assay (ELISA) (Bio-Rad, Marnes-la-Coquette, France) has become an important tool for the early detection of invasive aspergillosis in immunocompromised patients (4). This ELISA uses a rat monoclonal antibody (EB-A2) which reacts with -(1,5)-galactofuranose, a side chain of galactomannan (GM). Cross-reactivity of the Platelia ELISA wit...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

دوره 43 3  شماره 

صفحات  -

تاریخ انتشار 2006